Quick answer: Glucagon does not need to be refrigerated under normal conditions. As long as you store it at room temperature (20°C to 25°C) and protect it from heat, cold, and moisture, your glucagon will stay safe and effective.
If you're living in South Africa with diabetes, you know that when it comes to diabetes emergencies, glucagon is a powerful, life-saving tool. Whether in the form of an injectable kit or a nasal spray, this hormone plays a critical role in treating severe hypoglycemia. But to be effective, it must be stored properly.
In this guide, we'll walk you through everything you need to know about glucagon storage, glucagon storage temperature, and how to store glucagon safely and effectively at home in South Africa or on the go.
Related article: Does Insulin Need to Be Refrigerated? How to Store Your Pens & Vials Correctly?
If reading is not your thing, we have an alternative for you! Check out our video on the same topic:
What is Glucagon?
Glucagon is a hormone produced by the pancreas that helps raise blood sugar levels by triggering the liver to release stored glucose.
How does Glucagon work?
Glucagon works by stimulating the liver to convert glycogen into glucose, which is then released into the bloodstream. This rapid rise in blood sugar is critical during episodes of severe hypoglycemia when oral glucose is not an option
Why is proper Glucagon storage important?
In emergencies where blood sugar drops dangerously low (a condition known as severe hypoglycemia), glucagon can be injected or sprayed nasally to restore balance fast.
However, if not stored correctly, glucagon can lose its potency. That's why understanding proper glucagon storage practices is just as important as knowing how to use it.
Related article: Insulin Travel Cases, The Must-Have Companions for Diabetics!
Does a Glucagon injection kit need to be refrigerated?
The short answer is no, most modern glucagon kits do not need to be refrigerated under normal conditions.
Advances in glucagon formulations have made them more stable and easier to store, so you don't need to keep them in the fridge like older versions of the medication.
Products like the GlucaGen Hypo Kit (injectable) are specifically designed to be stored at room temperature.
This makes it much easier for people with diabetes or caregivers to keep glucagon on hand at school, work, or while traveling, without the hassle of refrigeration.
Can you refrigerate Glucagon?
While refrigeration is not required, some people prefer to keep backup glucagon kits in the fridge to extend their lifespan, as long as they follow the manufacturer's instructions.
If You Choose to Refrigerate
- Store glucagon between 2°C to 8°C if refrigeration is acceptable per the product insert.
- Do not freeze it. Freezing will render the medication unusable.
- Let it return to room temperature before use.
However, just because refrigeration isn't required doesn't mean storage conditions don't matter. Like any medication, glucagon is sensitive to extreme temperatures, which can impact how well it works when you need it most.
Glucagon storage temperature: room temperature guidelines and safety tips
Ideal storage temperature
The recommended glucagon storage temperature is between 20°C to 25°C.
As previously mentioned, this range applies to the most commonly used kit in South Africa the GlucaGen Hypo Kit (injectable).
This product does not require refrigeration when kept within the recommended range. However, storing it outside this range, especially in extreme heat or freezing conditions, can damage the medication and reduce its effectiveness.
Avoid extreme temperatures
When storing glucagon:
- ❄️ Do not freeze glucagon kits. Freezing can permanently degrade the medication.
- 🔥 Avoid temperatures above 30°C. Prolonged exposure to heat can break down the hormone.
- 🌞 Keep kits away from direct sunlight and heat sources like stoves, car interiors, or radiators.
Special considerations for hot climates and travel
If you are experiencing a hot South African summer or plan to travel to a warm environment, take extra precautions to keep your glucagon within a safe temperature range:
- Never store your kit in a glove box or checked luggage where temperatures can spike.
- Use an insulated cooling case or medical cooler bag to protect your glucagon on hot days.
- For extended travel, consider portable medical-grade cooling options to maintain stable conditions.
Storing your glucagon at the right temperature is just one part of making sure it's ready to use in an emergency.
Next, let's look at a few practical tips to keep your kit protected, accessible, and in good condition, so it's there for you when it matters most.
How to store Glucagon so it's ready when you need it
Knowing how to store glucagon goes beyond temperature-it's about making sure your kit is protected, accessible, and in good condition when a low blood sugar emergency happens. Here are some simple but important tips to keep your glucagon kit ready to go.
1. Keep It in Its Original Packaging
Glucagon kits come in sturdy, protective packaging designed to guard against light, moisture, and damage. Always keep your glucagon in its original case or box to help preserve its quality and ensure it's clearly labeled and easy to identify in an emergency.
2. Avoid Sunlight and Heat Sources
Even if your kit is at the right temperature, excessive light or direct heat can still impact its effectiveness. Avoid storing glucagon:
- On sunny windowsills
- In hot vehicles (especially in glove compartments or dashboards)
- Near radiators, stoves, or heating vents
Even moderate outdoor temperatures can cause bags or cars to heat up quickly, especially during travel or summer months.
3. Choose a Cool, Dry, and Stable Spot
Humidity and temperature fluctuations can degrade medication over time. Good places to keep your glucagon at home include:
- A bedroom drawer
- A closet shelf
- A kitchen cabinet away from appliances
💡Pro tip: Avoid storing it in bathrooms or near sinks where moisture levels are higher.
4. Make Sure It's Easy to Find
In an emergency, every second matters. Store your glucagon where it can be quickly located and accessed, whether that's in a home medicine cabinet, a dedicated drawer, or a labeled pouch in your bag. If you're often on the go, carrying it daily in a backpack, purse, or diabetes supply kit is a smart move.
You might also want to let friends, family members, or coworkers know where you keep your kit, especially if they might need to administer it on your behalf.
Related article: The Ultimate Checklist for Traveling With Diabetes.
How to Use a Glucagon Injection Kit (GlucaGen HypoKit)
If someone with diabetes experiences severe low blood sugar and can’t eat or drink, you may need to use a glucagon injection. The GlucaGen HypoKit must be mixed before use, so it’s important to familiarize friends and family with the steps:
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Open the orange box and follow the instructions inside the lid.
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Remove the syringe and pull off the grey needle cap.
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Snap off the orange cap on the vial, insert the needle through the rubber stopper, and inject the liquid into the vial with the powder.
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Gently shake until fully mixed into a clear solution.
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Draw the solution back into the syringe, being careful not to pull in air.
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Inject into the outer thigh: Pinch the skin, insert the needle, and push the plunger all the way down.
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Dosage: Children under 6 (or under 25kg) usually get 0.5mg. Older children and adults typically receive 1mg. Follow your doctor’s instructions.
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After injection, turn the person on their side to prevent choking in case of vomiting.
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Call emergency services immediately.
Where should you inject Glucagon?
The glucagon injection kit typically comes with instructions on how to use it and where to inject glucagon. For most products, common injection sites include:
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The upper arm
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The thigh
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The buttocks
Always follow the manufacturer’s instructions and consult your healthcare provider for proper technique.
Final thoughts: always follow instructions on Glucagon storage
Glucagon is a life-saving medication, but it's only useful if it's stored properly and ready when you need it.
By keeping your glucagon at the right temperature, avoiding common storage mistakes, and placing it somewhere accessible, you're ensuring peace of mind in the face of a potential emergency.
A little preparation goes a long way, especially when seconds count.
Key Take Aways:
❄️ No Fridge Needed: Most glucagon kits can safely be stored at room temperature between 20°C to 25°C.
🔥 Protect from Heat & Cold: Avoid exposing your kit to freezing temperatures or heat above 30°C, which can damage the medication.
📦 Store Smart: Keep it in its original packaging, out of direct sunlight, and away from moisture or hot surfaces.
🚨 Easy Access Matters: Whether at home or on the go, make sure your glucagon kit is easy to grab quickly in an emergency.
We'd love to hear from you!
💬 Have you ever had to use a glucagon kit? Do you have any clever tips for storing it safely while traveling or going about your day? Share your experiences or ask your questions in the comments section below. We're all in this together, and your story could help someone else stay safe.
